Glucocerebrosidase Defects as a Major Risk Factor for Parkinson’s Disease

Glucocerebrosidase Defects as a Major Risk Factor for Parkinson’s Disease

Heterozygous mutations of the GBA1 gene, encoding for lysosomal enzyme glucocerebrosidase (GCase), occur in a considerable percentage of all patients with sporadic Parkinson’s disease (PD), varying between 8% and 12% across the world. Genome wide association studies have confirmed the strong correla...

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Bibliographic Details
Main Authors: Micol Avenali, Fabio Blandini, Silvia Cerri
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
glucocerebrosidase
alpha-synuclein
GBA1
risk factor
synucleinopathy
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00097/full

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https://www.frontiersin.org/article/10.3389/fnagi.2020.00097/full

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