Bis(chloroacetamidino)-Derived Heteroarene-Fused Anthraquinones Bind to and Cause Proteasomal Degradation of tNOX, Leading to c-Flip Downregulation and Apoptosis in Oral Cancer Cells

Bis(chloroacetamidino)-Derived Heteroarene-Fused Anthraquinones Bind to and Cause Proteasomal Degradation of tNOX, Leading to c-Flip Downregulation and Apoptosis in Oral Cancer Cells

Anthraquinone-based intercalating compounds, namely doxorubicin and mitoxantrone, have been used clinically based on their capacity to bind DNA and induce DNA damage. However, their applications have been limited by side effects and drug resistance. New-generation anthraquinone derivatives fused wit...

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Bibliographic Details
Main Authors: Jeng Shiun Chang, Chien-Yu Chen, Alexander S. Tikhomirov, Atikul Islam, Ru-Hao Liang, Chia-Wei Weng, Wei-Hou Wu, Andrey E. Shchekotikhin, Pin Ju Chueh
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
anthraquinone
apoptosis
c-Flip downregulation
heterocyclic compounds
oral cancer cells
tumor-associated NADH oxidase (tNOX, ENOX2)
Online Access:https://www.mdpi.com/2072-6694/14/19/4719

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https://www.mdpi.com/2072-6694/14/19/4719

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