The PRMT5 inhibitor EPZ015666 is effective against HTLV-1-transformed T-cell lines in vitro and in vivo

The PRMT5 inhibitor EPZ015666 is effective against HTLV-1-transformed T-cell lines in vitro and in vivo

Human T-cell leukemia virus type 1 (HTLV-1) is the infectious cause of adult T-cell leukemia/lymphoma (ATL), an extremely aggressive and fatal malignancy of CD4+ T-cells. Due to the chemotherapy-resistance of ATL and the absence of long-term therapy regimens currently available for ATL patients, the...

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Bibliographic Details
Main Authors: Kyle Ernzen, Corrine Melvin, Lianbo Yu, Cameron Phelps, Stefan Niewiesk, Patrick L. Green, Amanda R. Panfil
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Microbiology
Subjects:
PRMT5
EPZ015666
HTLV-1
transformation
xenograft
humanized mice
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1101544/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1101544/full

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