Interleukin 23 Produced by Hepatic Monocyte-Derived Macrophages Is Essential for the Development of Murine Primary Biliary Cholangitis

Interleukin 23 Produced by Hepatic Monocyte-Derived Macrophages Is Essential for the Development of Murine Primary Biliary Cholangitis

Background and AimsPrimary Biliary Cholangitis (PBC) is an organ-specific autoimmune liver disease. Mononuclear phagocytes (MNPs), comprise of monocyte, dendritic cells and monocyte-derived macrophages, constitute major arm of the innate immune system known to be involved in the pathogenesis of auto...

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Bibliographic Details
Main Authors: Debby Reuveni, Miriam R. Brezis, Eli Brazowski, Philip Vinestock, Patrick S. C. Leung, Paresh Thakker, M. Eric Gershwin, Ehud Zigmond
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
primary biliary cholangitis
monocytes
macrophages
cytokines
interleukin-23
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.718841/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.718841/full

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