Performance of a Four-Antigen <i>Staphylococcus aureus</i> Vaccine in Preclinical Models of Invasive <i>S. aureus</i> Disease

Performance of a Four-Antigen <i>Staphylococcus aureus</i> Vaccine in Preclinical Models of Invasive <i>S. aureus</i> Disease

A <i>Staphylococcus aureus</i> four-antigen vaccine (SA4Ag) was designed for the prevention of invasive disease in surgical patients. The vaccine is composed of capsular polysaccharide type 5 and type 8 CRM<sub>197</sub> conjugates, a clumping factor A mutant (Y338A-ClfA) and...

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Bibliographic Details
Main Authors: Ingrid L. Scully, Yekaterina Timofeyeva, Arthur Illenberger, Peimin Lu, Paul A. Liberator, Kathrin U. Jansen, Annaliesa S. Anderson
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Microorganisms
Subjects:
<i>Staphylococcus aureus</i>
invasive disease
surgery-associated infection
sepsis
SA4Ag vaccine
conjugated polysaccharide
Online Access:https://www.mdpi.com/2076-2607/9/1/177

Internet

https://www.mdpi.com/2076-2607/9/1/177

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