Evidence for DNA cleavage caused directly by a transfer RNA-targeting toxin.

Evidence for DNA cleavage caused directly by a transfer RNA-targeting toxin.

The killer yeast species Pichiaacaciae produces a heteromeric killer protein, PaT, that causes DNA damage and arrests the cell cycle of sensitive Saccharomyces cerevisiae in the S phase. However, the mechanism by which DNA damage occurs remains elusive. A previous study has indicated that Orf2p, a s...

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Bibliographic Details
Main Authors: Megumi Shigematsu, Tetsuhiro Ogawa, Wataru Tanaka, Kazutoshi Takahashi, Hiroko K Kitamoto, Makoto Hidaka, Haruhiko Masaki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3775755?pdf=render

Internet

http://europepmc.org/articles/PMC3775755?pdf=render

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