Synergy between Membrane Currents Prevents Severe Bradycardia in Mouse Sinoatrial Node Tissue

Bradycardia is initiated by the sinoatrial node (SAN), which is regulated by a coupled-clock system. Due to the clock coupling, reduction in the ‘funny’ current (I<sub>f</sub>), which affects SAN automaticity, can be compensated, thus preventing severe bradycardia. We hypothesize that th...

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Bibliographic Details
Main Authors: Limor Arbel Ganon, Moran Davoodi, Alexandra Alexandrovich, Yael Yaniv
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/24/6/5786