Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice

Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice

Introduction: We previously demonstrated that magnesium ions (Mg2+) was a novel therapeutic alternative for osteoarthritis (OA) through promoting the hypoxia inducible factor-1α (HIF-1α)-mediated cartilage matrix synthesis. However, oxidative stress can inhibit the expression of HIF-1α, amplify the...

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Bibliographic Details
Main Authors: Hao Yao, Jiankun Xu, Jiali Wang, Yifeng Zhang, Nianye Zheng, Jiang Yue, Jie Mi, Lizhen Zheng, Bingyang Dai, Wenhan Huang, Shuhang Yung, Peijie Hu, Yechun Ruan, Qingyun Xue, Kiwai Ho, Ling Qin
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2021-05-01
Series:Bioactive Materials
Subjects:
Osteoarthritis
Magnesium
Vitamin C
Cartilage
Inflammation
Osteophyte
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X2030267X

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http://www.sciencedirect.com/science/article/pii/S2452199X2030267X

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