Pyrazinoic Acid Inhibits the Bifunctional Enzyme (Rv2783) in <i>Mycobacterium tuberculosis</i> by Competing with tmRNA

Pyrazinoic Acid Inhibits the Bifunctional Enzyme (Rv2783) in <i>Mycobacterium tuberculosis</i> by Competing with tmRNA

Pyrazinamide (PZA) is a key drug for tuberculosis treatment. The active form of PZA, pyrazinoic acid (POA), appears to inhibit multiple targets in <i>M. tuberculosis.</i> Recently, the bifunctional enzyme Rv2783 was reported as a new target of POA. However, the mechanism by which POA inh...

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Bibliographic Details
Main Authors: Lei He, Peng Cui, Wanliang Shi, Qiong Li, Wenhong Zhang, Min Li, Ying Zhang
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Pathogens
Subjects:
mycobacterium tuberculosis
pyrazinamide resistance
<i>rv2783c</i> gene
pnpase
tmrna
Online Access:https://www.mdpi.com/2076-0817/8/4/230

Internet

https://www.mdpi.com/2076-0817/8/4/230

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