Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model

Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model

Muscle weakness and cachexia are significant paraneoplastic syndromes of many advanced cancers. Osteolytic bone metastases are common in advanced breast cancer and are a major contributor to decreased survival, performance, and quality of life for patients. Pathologic fracture caused by osteolytic c...

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Bibliographic Details
Main Authors: Jenna N. Regan, Carter Mikesell, Steven Reiken, Haifang Xu, Andrew R. Marks, Khalid S. Mohammad, Theresa A. Guise, David L. Waning
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Endocrinology
Subjects:
breast cancer
osteolytic disease
muscle weakness
immune competent
syngeneic tumor model
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00358/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2017.00358/full

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