AOP key event relationship report: Linking androgen receptor antagonism with nipple retention

AOP key event relationship report: Linking androgen receptor antagonism with nipple retention

In rat developmental and reproductive toxicity studies, nipple/areola retention (NR) in male offspring is a biomarker for reduced androgen signaling during development. This is because nipples normally regress in male rats in response to androgen signaling during critical stages of development. NR i...

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Bibliographic Details
Main Authors: Emilie Bak Pedersen, Sofie Christiansen, Terje Svingen
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Toxicology
Subjects:
AOP
KER
Androgen receptor
Nipples
Reproductive toxicology
Endocrine disrupting chemicals
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X22000226

Internet

http://www.sciencedirect.com/science/article/pii/S2666027X22000226

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