Parenteral Exposure of Mice to Ricin Toxin Induces Fatal Hypoglycemia by Cytokine-Mediated Suppression of Hepatic Glucose-6-Phosphatase Expression

Parenteral Exposure of Mice to Ricin Toxin Induces Fatal Hypoglycemia by Cytokine-Mediated Suppression of Hepatic Glucose-6-Phosphatase Expression

Ricin toxin is an agent of biodefense concern and we have been developing countermeasures for ricin threats. In doing so, we sought biomarkers of ricin toxicosis and found that in mice parenteral injection of ricin toxin causes profound hypoglycemia, in the absence of other clinical laboratory abnor...

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Bibliographic Details
Main Authors: Seth H. Pincus, Alexi Kyro, Grace A. Maresh, Tami Peters, Jacob Kempa, Tamera K. Marcotte, Zhanguo Gao, Jianping Ye, Valérie Copié, Kejing Song
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Toxins
Subjects:
glucose metabolism
hypoglycemia
insulin
ricin
toxin
TNF-α
Online Access:https://www.mdpi.com/2072-6651/14/12/820

Internet

https://www.mdpi.com/2072-6651/14/12/820

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