Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression

Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression

The multi-functional cytokine transforming growth factor-β1 (TGF-β1) has growth inhibitory and anti-inflammatory roles during homeostasis and the early stages of cancer. Aberrant TGF-β activation in the late-stages of tumorigenesis, however, promotes development of aggress...

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Bibliographic Details
Main Authors: Jiaqi Tang, Cody C. Gifford, Rohan Samarakoon, Paul J. Higgins
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Cancers
Subjects:
transforming growth factor-β1
PTEN
PPM1A
Klotho
SMAD7
BMP7
Ski/Sno
BAMBI
tumor progression
cellular plasticity
Online Access:http://www.mdpi.com/2072-6694/10/6/159

Internet

http://www.mdpi.com/2072-6694/10/6/159

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