PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation

PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of inherited and sporadic Parkinson’s disease (PD) and previous work suggests that dephosphorylation of LRRK2 at a cluster of heterologous phosphosites is associated to disease. We have previously reported subunits of the PP1 and P...

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Main Authors: Lucia Iannotta, Marco Emanuele, Giulia Favetta, Giulia Tombesi, Laurine Vandewynckel, Antonio Jesús Lara Ordóñez, Jean-Michel Saliou, Matthieu Drouyer, William Sibran, Laura Civiero, R. Jeremy Nichols, Panagiotis S. Athanasopoulos, Arjan Kortholt, Marie-Christine Chartier-Harlin, Elisa Greggio, Jean-Marc Taymans
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
LRRK2
Parkinson’s disease
dephosphorylation
PP2A
PPP2R2C
Pak6
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1269387/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1269387/full

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