Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling

Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling

Introduction: More than 50 mutations in the MAPT gene result in heterogeneous forms of frontotemporal lobar dementia with tau inclusions (FTLD-Tau). However, early pathogenic events that lead to disease and the degree to which they are common across MAPT mutations remain poorly understood. The goal...

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Bibliographic Details
Main Authors: Miguel A. Minaya, Sidhartha Mahali, Abhirami K. Iyer, Abdallah M. Eteleeb, Rita Martinez, Guangming Huang, John Budde, Sally Temple, Alissa L. Nana, William W. Seeley, Salvatore Spina, Lea T. Grinberg, Oscar Harari, Celeste M. Karch
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
IPSC-derived neurons
frontotemporal dementia (FTD)
MAPT mutations (tau)
transcriptomics
calcium signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1051494/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1051494/full

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