Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice

Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice

ABSTRACTMillions suffer from urinary tract infections (UTIs) worldwide every year with women accounting for the majority of cases. Uropathogenic Escherichia coli (UPEC) causes most of these primary infections and leads to 25% becoming recurrent or chronic. To repel invading pathogens, the urinary tr...

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Bibliographic Details
Main Authors: Anne L. Rosen, Michael A. Lint, Dayne H. Voelker, Nicole M. Gilbert, Christopher P. Tomera, Jesús Santiago-Borges, Meghan A. Wallace, Thomas J. Hannan, Carey-Ann D. Burnham, Scott J. Hultgren, Andrew L. Kau
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
uropathogenic Escherichia coli (UPEC)
secretory leukocyte protease inhibitor (SLPI)
urinary tract infection (UTI)
innate immunity
antimicrobial peptide (AMP)
protease inhibitor
Online Access:https://journals.asm.org/doi/10.1128/mbio.02554-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02554-23

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