Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice

Secretory leukocyte protease inhibitor protects against severe urinary tract infection in mice

ABSTRACTMillions suffer from urinary tract infections (UTIs) worldwide every year with women accounting for the majority of cases. Uropathogenic Escherichia coli (UPEC) causes most of these primary infections and leads to 25% becoming recurrent or chronic. To repel invading pathogens, the urinary tr...

Full description

Bibliographic Details
Main Authors:	Anne L. Rosen, Michael A. Lint, Dayne H. Voelker, Nicole M. Gilbert, Christopher P. Tomera, Jesús Santiago-Borges, Meghan A. Wallace, Thomas J. Hannan, Carey-Ann D. Burnham, Scott J. Hultgren, Andrew L. Kau
Format:	Article
Language:	English
Published:	American Society for Microbiology 2024-02-01
Series:	mBio
Subjects:	uropathogenic Escherichia coli (UPEC) secretory leukocyte protease inhibitor (SLPI) urinary tract infection (UTI) innate immunity antimicrobial peptide (AMP) protease inhibitor
Online Access:	https://journals.asm.org/doi/10.1128/mbio.02554-23

Similar Items

Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation
by: Natalia Jaeger, et al.
Published: (2020-11-01)

Overexpression and pre-treatment of recombinant human Secretory Leukocyte Protease Inhibitor (rhSLPI) reduces an in vitro ischemia/reperfusion injury in rat cardiac myoblast (H9c2) cell
by: Prompunt Eakkapote, et al.
Published: (2018-05-01)

Adeno-associated virus 9 vector-mediated cardiac-selective expression of human secretory leukocyte protease inhibitor attenuates myocardial ischemia/reperfusion injury
by: Podsawee Mongkolpathumrat, et al.
Published: (2022-08-01)

Post-Ischemic Treatment of Recombinant Human Secretory Leukocyte Protease Inhibitor (rhSLPI) Reduced Myocardial Ischemia/Reperfusion Injury
by: Podsawee Mongkolpathumrat, et al.
Published: (2021-04-01)

Gelatin-coated silicon oxide nanoparticles encapsulated recombinant human secretory leukocyte protease inhibitor (rhSLPI) reduced cardiac cell death against an in vitro simulated ischaemia/reperfusion injury
by: Faprathan Pikwong, et al.
Published: (2023-09-01)

Spatiotemporal expression and regulation of peptidase inhibitor 3 and secretory leukocyte protease inhibitor at the maternal–fetal interface in pigs
by: Soohyung Lee, et al.
Published: (2023-07-01)

Targeting secretory leukocyte protease inhibitor (SLPI) inhibits colorectal cancer cell growth, migration and invasion via downregulation of AKT
by: Zhijiang Wei, et al.
Published: (2020-07-01)

Endothelial-Cell-Derived Human Secretory Leukocyte Protease Inhibitor (SLPI) Protects Cardiomyocytes against Ischemia/Reperfusion Injury
by: Kantapich Kongpol, et al.
Published: (2019-10-01)

The Role of Recombinant Secretory Leukocyte Protease Inhibitor to CD163, FGF-2, IL-1 and IL-6 Expression in Skin Wound Healing
by: Munadziroh E, et al.
Published: (2022-05-01)

Role of salivary leukocyte protease inhibitor in periodontal disease progression
by: Pateel Deepak, et al.
Published: (2010-01-01)

Anti-Protease Activity Deficient Secretory Leukocyte Protease Inhibitor (SLPI) Exerts Cardioprotective Effect against Myocardial Ischaemia/Reperfusion
by: Podsawee Mongkolpathumrat, et al.
Published: (2022-04-01)

Secretory Leucoprotease Inhibitor (SLPI) Promotes Survival during Acute <i>Pseudomonas aeruginosa</i> Infection by Suppression of Inflammation Rather Than Microbial Killing
by: Megan Osbourn, et al.
Published: (2022-11-01)

Secreotory Leukocyte Protease Inhibitor Regulates Bone Formation via RANKL, OPG, and Runx2 in Rat Periodontitis and MC3T3-E1 Preosteoblast
by: Seung-Yeon Lee, et al.
Published: (2023-12-01)

Secretory Leukocyte Protease Inhibitor Is Present in Circulating and Tissue-Recruited Human Eosinophils and Regulates Their Migratory Function
by: Oktawia Osiecka, et al.
Published: (2022-01-01)

Inhibition of secretory leukocyte protease inhibitor (SLPI) promotes the PUMA-mediated apoptosis and chemosensitivity to cisplatin in colorectal cancer cells
by: Zhijiang Wei, et al.
Published: (2023-01-01)

Up‐regulation of secretory leukocyte protease inhibitor in human samples might have a potential role of predicting prostate cancer recurrence and progression after surgery and hormonal therapy
by: Yu Miyazaki, et al.
Published: (2023-02-01)

Cytokines and SLPI profiles in children and adults with urinary tract infections
by: M. Kolesnуk, et al.
Published: (2019-12-01)

Secretory leukocyte protease inhibitor suppresses HPV E6-expressing HNSCC progression by mediating NF-κB and Akt pathways
by: Yu Jin, et al.
Published: (2019-08-01)

Neutrophil elastase in cervical fluid in women with short cervical length
by: Soo Ran Choi, et al.
Published: (2018-06-01)

Secretory leukocyte protease inhibitor as a novel predictive biomarker in patients with diabetic kidney disease
by: Weiwei Sun, et al.
Published: (2024-03-01)

Neutrophils and Activated Macrophages Control Mucosal Immunity by Proteolytic Cleavage of Antileukoproteinase
by: Jennifer Vandooren, et al.
Published: (2018-05-01)

Cervical expression of elafin and secretory leukocyte peptidase inhibitor does not predict preterm delivery in twin pregnancy – results from a pilot study
by: Aleksandra Saletra-Bielińska, et al.
Published: (2021-02-01)

Dietary iron modulates gut microbiota and induces SLPI secretion to promote colorectal tumorigenesis
by: Chen Liu, et al.
Published: (2023-12-01)

The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease
by: Sallenave Jean-Michel
Published: (2000-08-01)

Effects Of Zno Nanoparticles on Initial Adhesion and fimH Gene Expression Level of Uropathogenic Eschercia coli
by: Ali Shakerimoghaddam, et al.
Published: (2017-10-01)

Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased Influenza A virus cleavage and replication
by: Kesic Matthew J, et al.
Published: (2012-09-01)

Triclabendazole Effect on Protease Enzyme Activity in the Excretory- Secretory Products of Fasciola hepatica in Vitro
by: Yosef Shrifi, et al.
Published: (2014-03-01)

The Gene Expression Profile of Uropathogenic <named-content content-type="genus-species">Escherichia coli</named-content> in Women with Uncomplicated Urinary Tract Infections Is Recapitulated in the Mouse Model
by: Arwen E. Frick-Cheng, et al.
Published: (2020-08-01)

Excretory/secretory proteases and mechanical movement of Anisakis pegreffii infective larvae in the penetration of BALB/c mice gastrointestine
by: June-Der Lee, et al.
Published: (2017-12-01)

Defining the Protease and Protease Inhibitor (P/PI) Proteomes of Healthy and Diseased Human Skin by Modified Systematic Review
by: Callum Stewart-McGuinness, et al.
Published: (2022-03-01)

Respiratory syncytial virus (RSV) entry is inhibited by serine protease inhibitor AEBSF when present during an early stage of infection
by: Winke Van der Gucht, et al.
Published: (2017-08-01)

Anthelmintic activity of Leucaena leucocephala protein extracts on Haemonchus contortus
by: Alexandra Martins dos Santos Soares, et al.

The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases
by: Gonzalo Izaguirre
Published: (2019-09-01)

Effects Of Zno Nanoparticles on Initial Adhesion and fimH Gene Expression Level of Uropathogenic Eschercia coli
by: Ali Shakerimoghaddam, et al.
Published: (2017-10-01)

Biofilm and hemagglutinin formation: a Hallmark for drug resistant uropathogenic Escherichia coli
by: Dawit Gebreegziabiher Hagos, et al.
Published: (2019-06-01)

Plant protease inhibitors : significance in nutrition, plant protection, cancer prevention, and genetic engineering /
by: 407348 Birk, Yehudith
Published: (2003)

Regulation of carcinogenesis, angiogenesis and metastasis by the proprotein convertases (PCs) : a new potential strategy in cancer therapy /
by: Khatib, A-Majid
Published: (2006)

Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis
by: Sandrine Nugteren, et al.
Published: (2020-01-01)

Cocaprins, β-Trefoil Fold Inhibitors of Cysteine and Aspartic Proteases from <i>Coprinopsis cinerea</i>
by: Miha Renko, et al.
Published: (2022-04-01)

Current and Novel Inhibitors of HIV Protease
by: Jan Konvalinka, et al.
Published: (2009-12-01)