Nanoparticles (NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy

Nanoparticles (NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy

T cell infiltration and proliferation in tumor tissues are the main factors that significantly affect the therapeutic outcomes of cancer immunotherapy. Emerging evidence has shown that interferon-gamma (IFNγ) could enhance CXCL9 secretion from macrophages to recruit T cells, but Siglec15 expressed o...

Full description

Bibliographic Details
Main Authors: Xiaodi Liu, Qi Zhang, Yixia Liang, Shiyu Xiong, Yan Cai, Jincheng Cao, Yanni Xu, Xiaolin Xu, Ye Wu, Qiang Lu, Xiaoding Xu, Baoming Luo
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Nanoparticles
Tumor-associated macrophages
Macrophage repolarization
T cell infiltration
T cell proliferation
Cancer immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523002733

Internet

http://www.sciencedirect.com/science/article/pii/S2211383523002733

Similar Items