Cigarette smoking inhibits myoblast regeneration by promoting proteasomal degradation of NPAT protein and hindering cell cycle progression

Cigarette smoking inhibits myoblast regeneration by promoting proteasomal degradation of NPAT protein and hindering cell cycle progression

Cigarette smoking (CS) causes skeletal muscle dysfunction, leading to sarcopenia and worse prognosis of patients with diverse systemic diseases. Here, we found that CS exposure prevented C2C12 myoblasts proliferation in a dose-dependent manner. Immunoblotting assays verified that CS exposure promote...

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Bibliographic Details
Main Authors: Jianfeng Wang, Jinling Liu, Jingjing Shao, Hongyu Chen, Luyun Cui, Pei Zhang, Yinan Yao, Jianying Zhou, Zhang Bao
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Current Research in Toxicology
Subjects:
Cigarette smoking
Myoblast proliferation
Cell cycle
NPAT
Proteasome
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X24000148

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http://www.sciencedirect.com/science/article/pii/S2666027X24000148

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