Acetogenins-Rich Fractions of <i>Annona coriacea</i> Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro

Acetogenins-Rich Fractions of <i>Annona coriacea</i> Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro

Glioblastoma (GBM) is an incurable primary brain tumor with a poor prognosis. Resection, radiation therapy, and temozolomide (TMZ) are insufficient to increase survival, making the treatment limited. Thus, the search for more effective and specific treatments is essential, making plants a promising...

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Bibliographic Details
Main Authors: Lorena R. Sousa, Ana Gabriela S. Oliveira, Antônio Arantes, João Gabriel M. Junqueira, Gerso P. Alexandre, Vanessa G. P. Severino, Rui Manuel Reis, Bonglee Kim, Rosy I. M. A. Ribeiro
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
acetogenins
GBM
natural product
Annonaceae
mechanism of death
gliomas
Online Access:https://www.mdpi.com/1420-3049/28/9/3809

Internet

https://www.mdpi.com/1420-3049/28/9/3809

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