The mutation of BCOR is highly recurrent and oncogenic in mature T-cell lymphoma

The mutation of BCOR is highly recurrent and oncogenic in mature T-cell lymphoma

Abstract Background BCOR acts as a corepressor of BCL6, a potent oncogenic protein in cancers of the lymphoid lineage. We have found the recurrent somatic mutation of BCOR occurred in mature T-cell lymphoma (TCL). The role of BCOR mutation in lymphoid malignancies is unknown. Methods Lymphoma patien...

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Bibliographic Details
Main Authors: Jin Hyun Kang, Seung Ho Lee, Jawon Lee, Murim Choi, Junhun Cho, Seok Jin Kim, Won Seog Kim, Young Hyeh Ko, Hae Yong Yoo
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Cancer
Subjects:
BCOR
T-cell lymphoma
BCL6
Gene mutation
HOX
S100 protein
Online Access:https://doi.org/10.1186/s12885-021-07806-8

Internet

https://doi.org/10.1186/s12885-021-07806-8

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