Formulation and Biological Evaluation of Mesoporous Silica Nanoparticles Loaded with Combinations of Sortase A Inhibitors and Antimicrobial Peptides

Formulation and Biological Evaluation of Mesoporous Silica Nanoparticles Loaded with Combinations of Sortase A Inhibitors and Antimicrobial Peptides

This study aimed to develop synergistic therapies to treat superbug infections through the encapsulation of sortase A inhibitors (SrtAIs; <i>trans</i>-chalcone (TC), curcumin (CUR), quercetin (QC), or berberine chloride (BR)) into MCM-41 mesoporous silica nanoparticles (MSNs) or a phosph...

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Bibliographic Details
Main Authors: Sitah Alharthi, Zyta M. Ziora, Taskeen Janjua, Amirali Popat, Peter M. Moyle
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
antimicrobial peptides
antimicrobial resistance
mesoporous silica nanoparticles
sortase A inhibitors
synergy
Online Access:https://www.mdpi.com/1999-4923/14/5/986

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https://www.mdpi.com/1999-4923/14/5/986

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