Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies

Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies

Abstract Hepatitis C virus (HCV) is a major global health burden as the leading causative agent of chronic liver disease and hepatocellular carcinoma. While the main antigenic target for HCV-neutralizing antibodies is the membrane-associated E1E2 surface glycoprotein, the development of effective va...

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Bibliographic Details
Main Authors: Matthew C. Metcalf, Benjamin M. Janus, Rui Yin, Ruixue Wang, Johnathan D. Guest, Edwin Pozharski, Mansun Law, Roy A. Mariuzza, Eric A. Toth, Brian G. Pierce, Thomas R. Fuerst, Gilad Ofek
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39659-z

Internet

https://doi.org/10.1038/s41467-023-39659-z

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