Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis

Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis

Abstract High‐risk endometrial cancer has poor prognosis and is increasing in incidence. However, understanding of the molecular mechanisms which drive this disease is limited. We used genetically engineered mouse models (GEMM) to determine the functional consequences of missense and loss of functio...

Full description

Bibliographic Details
Main Authors: Matthew Brown, Alicia Leon, Katarzyna Kedzierska, Charlotte Moore, Hayley L Belnoue‐Davis, Susanne Flach, John P Lydon, Francesco J DeMayo, Annabelle Lewis, Tjalling Bosse, Ian Tomlinson, David N Church
Format: Article
Language:English
Published: Springer Nature 2023-10-01
Series:EMBO Molecular Medicine
Subjects:
Driver genes
Endometrial cancer
Fbxw7
Functional models
GEMM
Online Access:https://doi.org/10.15252/emmm.202217094

Internet

https://doi.org/10.15252/emmm.202217094

Similar Items