Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251
Mucosal surfaces are a primary route of HIV entry, yet the compartmentalisation between mucosal and peripheral immune systems remain a challenge for HIV vaccine candidates. Authors utilise a combination of intranodal tonsil MALT and systemic vaccination in the rhesus macaque model to explore immune...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36907-0 |
| _version_ | 1797864281526501376 |
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| author | Jeffy G. Mattathil Asisa Volz Olusegun O. Onabajo Sean Maynard Sandra L. Bixler Xiaoying X. Shen Diego Vargas-Inchaustegui Marjorie Robert-Guroff Celia Lebranche Georgia Tomaras David Montefiori Gerd Sutter Joseph J. Mattapallil |
| author_facet | Jeffy G. Mattathil Asisa Volz Olusegun O. Onabajo Sean Maynard Sandra L. Bixler Xiaoying X. Shen Diego Vargas-Inchaustegui Marjorie Robert-Guroff Celia Lebranche Georgia Tomaras David Montefiori Gerd Sutter Joseph J. Mattapallil |
| author_sort | Jeffy G. Mattathil |
| collection | DOAJ |
| description | Mucosal surfaces are a primary route of HIV entry, yet the compartmentalisation between mucosal and peripheral immune systems remain a challenge for HIV vaccine candidates. Authors utilise a combination of intranodal tonsil MALT and systemic vaccination in the rhesus macaque model to explore immune responses and protection from highly pathogenic simian homologue of HIV. |
| first_indexed | 2024-04-09T22:49:18Z |
| format | Article |
| id | doaj.art-5c95e638f47643898cb93e8cea9c171f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:49:18Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5c95e638f47643898cb93e8cea9c171f2023-03-22T11:41:39ZengNature PortfolioNature Communications2041-17232023-03-0114111510.1038/s41467-023-36907-0Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251Jeffy G. Mattathil0Asisa Volz1Olusegun O. Onabajo2Sean Maynard3Sandra L. Bixler4Xiaoying X. Shen5Diego Vargas-Inchaustegui6Marjorie Robert-Guroff7Celia Lebranche8Georgia Tomaras9David Montefiori10Gerd Sutter11Joseph J. Mattapallil12Henry M. Jackson Foundation for Military MedicineInstitute of Virology, University of Veterinary Medicine HannoverHenry M. Jackson Foundation for Military MedicineHenry M. Jackson Foundation for Military MedicineHenry M. Jackson Foundation for Military MedicineDuke University School of MedicineNational Cancer InstituteNational Cancer InstituteDuke University School of MedicineDuke University School of MedicineDuke University School of MedicineDivision of Virology, Department of Veterinary Sciences, LMUDepartment of Microbiology and Immunology, Uniformed Services UniversityMucosal surfaces are a primary route of HIV entry, yet the compartmentalisation between mucosal and peripheral immune systems remain a challenge for HIV vaccine candidates. Authors utilise a combination of intranodal tonsil MALT and systemic vaccination in the rhesus macaque model to explore immune responses and protection from highly pathogenic simian homologue of HIV.https://doi.org/10.1038/s41467-023-36907-0 |
| spellingShingle | Jeffy G. Mattathil Asisa Volz Olusegun O. Onabajo Sean Maynard Sandra L. Bixler Xiaoying X. Shen Diego Vargas-Inchaustegui Marjorie Robert-Guroff Celia Lebranche Georgia Tomaras David Montefiori Gerd Sutter Joseph J. Mattapallil Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251 Nature Communications |
| title | Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251 |
| title_full | Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251 |
| title_fullStr | Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251 |
| title_full_unstemmed | Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251 |
| title_short | Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251 |
| title_sort | direct intranodal tonsil vaccination with modified vaccinia ankara vaccine protects macaques from highly pathogenic sivmac251 |
| url | https://doi.org/10.1038/s41467-023-36907-0 |
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