Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection.

Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection.

OBJECTIVES:As the HIV-infected population ages, the role of cellular senescence and inflammation on co-morbid conditions and pharmacotherapy is increasingly of interest. p16INK4a expression, a marker for aging and senescence in T-cells, is associated with lower intracellular concentrations of endoge...

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Bibliographic Details
Main Authors: Brian M Maas, Owen Francis, Katie R Mollan, Cynthia Lee, Mackenzie L Cottrell, Heather M A Prince, Craig Sykes, Christine Trezza, Chad Torrice, Nicole White, Stephanie Malone, Michael G Hudgens, Norman E Sharpless, Julie B Dumond
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5201235?pdf=render

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http://europepmc.org/articles/PMC5201235?pdf=render

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