No detectable truncating mutations in large T antigen (LT-Ag) sequence of Merkel cell polyomavirus (MCPyV) DNA obtained from porocarcinomas

No detectable truncating mutations in large T antigen (LT-Ag) sequence of Merkel cell polyomavirus (MCPyV) DNA obtained from porocarcinomas

Abstract Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma (MCC). In tumor cells the MCPyV large T antigen (LT-Ag) is frequently found truncated and this is considered a major tumor-specific signature. The role of MCPyV in other, non-MCC tumours, is little known. Viral DNA an...

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Bibliographic Details
Main Authors: Rosaria Arvia, Mauro Sollai, Daniela Massi, Patricia Asensio-Calavia, Carmelo Urso, Krystyna Zakrzewska
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Infectious Agents and Cancer
Subjects:
Merkel cell polyomavirus
Porocarcinoma
MCPyV large T antigen
FFPE samples
Online Access:https://doi.org/10.1186/s13027-024-00568-5

Internet

https://doi.org/10.1186/s13027-024-00568-5

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