Cancer genes hypermethylated in human embryonic stem cells.

Cancer genes hypermethylated in human embryonic stem cells.

Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant...

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Bibliographic Details
Main Authors: Vincenzo Calvanese, Angelica Horrillo, Abdelkrim Hmadcha, Beatriz Suarez-Alvarez, Agustín F Fernandez, Ester Lara, Sara Casado, Pablo Menendez, Clara Bueno, Javier Garcia-Castro, Ruth Rubio, Pablo Lapunzina, Miguel Alaminos, Lodovica Borghese, Stefanie Terstegge, Neil J Harrison, Harry D Moore, Oliver Brüstle, Carlos Lopez-Larrea, Peter W Andrews, Bernat Soria, Manel Esteller, Mario F Fraga
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2546447?pdf=render

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http://europepmc.org/articles/PMC2546447?pdf=render

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