In silico-guided metabolic engineering of Bacillus subtilis for efficient biosynthesis of purine nucleosides by blocking the key backflow nodes

In silico-guided metabolic engineering of Bacillus subtilis for efficient biosynthesis of purine nucleosides by blocking the key backflow nodes

Abstract Background Purine nucleosides play essential roles in cellular physiological processes and have a wide range of applications in the fields of antitumor/antiviral drugs and food. However, microbial overproduction of purine nucleosides by de novo metabolic engineering remains a great challeng...

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Bibliographic Details
Main Authors: Aihua Deng, Qidi Qiu, Qinyun Sun, Zhenxiang Chen, Junyue Wang, Yu Zhang, Shuwen Liu, Tingyi Wen
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Biotechnology for Biofuels and Bioproducts
Subjects:
Bacillus subtilis
Genome-scale metabolic network model
Metabolic engineering
Backflow node
Purine nucleosides
Chassis bacterium
Online Access:https://doi.org/10.1186/s13068-022-02179-x

Internet

https://doi.org/10.1186/s13068-022-02179-x

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