Glucuronidation of oxidized fatty acids and prostaglandins B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases

Glucuronidation of oxidized fatty acids and prostaglandins B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases

Arachidonic acid (AA) can be metabolized to various metabolites, which can act as mediators of cellular processes. The objective of this work was to identify whether AA, prostaglandin (PG) B1 and E2, and 15- and 20-hydroxyeicosatetraenoic acids (15- and 20-HETE) are metabolized via glucuronidation....

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Bibliographic Details
Main Authors: Joanna M. Little, Mika Kurkela, Julia Sonka, Sirkku Jäntti, Raimo Ketola, Stacie Bratton, Moshe Finel, Anna Radominska-Pandya
Format: Article
Language:English
Published: Elsevier 2004-09-01
Series:Journal of Lipid Research
Subjects:
uridine diphosphate-glucuronosyltransferase
prostaglandins
hydroxyeicosatetraenoic acid
human liver
human intestine
liquid chromatography-mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520312864

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http://www.sciencedirect.com/science/article/pii/S0022227520312864

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