Reciprocal Interferences of TNF-α and Wnt1/β-Catenin Signaling Axes Shift Bone Marrow-Derived Stem Cells Towards Osteoblast Lineage after Ethanol Exposure

Reciprocal Interferences of TNF-α and Wnt1/β-Catenin Signaling Axes Shift Bone Marrow-Derived Stem Cells Towards Osteoblast Lineage after Ethanol Exposure

Background/Aims: We have reported in a separate study that alcohol exposure triggers activation of the TNF-α signaling pathway leading to an adverse shift of multipotential mesenchymal stem cells in bone marrow (BMSCs) away from osteogenesis towards adipogenesis. However, inhibition of TNF-α signali...

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Bibliographic Details
Main Authors: Yueping Chen, Liang Chen, Qingshui Yin, Hui Gao, Panfeng Dong, Xiaoyun Zhang, Jie Kang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Ethanol
Multipotential mesenchymal stem cells (MSC)
Bone-marrow stem cells (BMSC)
Osteoblast
Osteogenesis
Adipogenisis
TNF-α
Wnt1
β-catenin
siRNA
Online Access:http://www.karger.com/Article/FullText/354477

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http://www.karger.com/Article/FullText/354477

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