Harnessing the IL-21-BATF Pathway in the CD8<sup>+</sup> T Cell Anti-Tumor Response
In cancer, CD8<sup>+</sup> T cells enter a dysfunctional state which prevents them from effectively targeting and killing tumor cells. Tumor-infiltrating CD8<sup>+</sup> T cells consist of a heterogeneous population of memory-like progenitor, effector, and terminally exhauste...
Main Authors: | Paytsar Topchyan, Gang Xin, Yao Chen, Shikan Zheng, Robert Burns, Jian Shen, Moujtaba Y. Kasmani, Matthew Kudek, Na Yang, Weiguo Cui |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-03-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/13/6/1263 |
Similar Items
-
BATF and BATF3 deficiency alters CD8+ effector/exhausted T cells balance in skin transplantation
by: Chenghao Li, et al.
Published: (2024-01-01) -
Single-Cell Transcriptomics Reveals Core Regulatory Programs That Determine the Heterogeneity of Circulating and Tissue-Resident Memory CD8<sup>+</sup> T Cells
by: Yao Chen, et al.
Published: (2021-08-01) -
BATF is Required for Treg Homeostasis and Stability to Prevent Autoimmune Pathology
by: Achia Khatun, et al.
Published: (2023-10-01) -
IL-21, Inflammatory Cytokines and Hyperpolarized CD8<sup>+</sup> T Cells Are Central Players in Lupus Immune Pathology
by: Soumya Sengupta, et al.
Published: (2023-01-01) -
Tox induces T cell IL-10 production in a BATF-dependent manner
by: D. Alejandro Canaria, et al.
Published: (2023-11-01)