AAV9‐mediated AIRE gene delivery clears circulating antibodies and tissue T‐cell infiltration in a mouse model of autoimmune polyglandular syndrome type‐1

AAV9‐mediated AIRE gene delivery clears circulating antibodies and tissue T‐cell infiltration in a mouse model of autoimmune polyglandular syndrome type‐1

Abstract Objectives Autoimmune polyglandular syndrome type‐1 (APS‐1) is a monogenic recessive disorder characterised by multiple endocrine abnormalities, chronic mucocutaneous candidiasis and high titres of serum autoantibodies. To date, no curative treatment is available; current therapies manage t...

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Bibliographic Details
Main Authors: Sarah Almaghrabi, Mimoun Azzouz, Rachid Tazi Ahnini
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical & Translational Immunology
Subjects:
autoimmune polyglandular syndrome type‐1
adeno‐associated virus serotype 9
autoimmune regulator gene
intrathymic injection
gene therapy
Online Access:https://doi.org/10.1002/cti2.1166

Internet

https://doi.org/10.1002/cti2.1166

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