Accelerated aging in normal breast tissue of women with breast cancer

Abstract Background DNA methylation alterations have similar patterns in normal aging tissue and in cancer. In this study, we investigated breast tissue-specific age-related DNA methylation alterations and used those methylation sites to identify individuals with outlier phenotypes. Outlier phenotyp...

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Bibliographic Details
Main Authors: Shoghag Panjarian, Jozef Madzo, Kelsey Keith, Carolyn M. Slater, Carmen Sapienza, Jaroslav Jelinek, Jean-Pierre J. Issa
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Breast Cancer Research
Subjects:
Online Access:https://doi.org/10.1186/s13058-021-01434-7