Less airway inflammation and goblet cell metaplasia in an IL-33-induced asthma model of leptin-deficient obese mice

Less airway inflammation and goblet cell metaplasia in an IL-33-induced asthma model of leptin-deficient obese mice

Abstract Background Obesity-associated asthma is a phenotype of severe asthma. Late-onset, non-eosinophilic and female-dominant phenotype is highly symptomatic and difficult to treat. Leptin, an adipokine, exerts an immunomodulatory effect. IL-33 associated with innate immunity induces type 2 inflam...

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Bibliographic Details
Main Authors: Atsushi Kurokawa, Mitsuko Kondo, Ken Arimura, Shigeru Ashino, Etsuko Tagaya
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Respiratory Research
Subjects:
Airway hyperresponsiveness
Asthma
Eosinophils
Goblet cell metaplasia
IL-33
Innate immunity
Online Access:https://doi.org/10.1186/s12931-021-01763-3

Internet

https://doi.org/10.1186/s12931-021-01763-3

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