Strategies that regulate LSD1 for novel therapeutics

Strategies that regulate LSD1 for novel therapeutics

Histone methylation plays crucial roles in regulating chromatin structure and gene transcription in epigenetic modifications. Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is universally overexpressed in various diseases. LSD1 dysregulation is closely associated wit...

Full description

Bibliographic Details
Main Authors: Meng Li, Mengge Dai, Bing Cheng, Shaotong Li, Enhui Guo, Junwei Fu, Ting Ma, Bin Yu
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
LSD1 regulation
Transcription repression
Transcription activation
the Corepressor complex
Post-transcriptional modifications
Metabolites
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524000078

Internet

http://www.sciencedirect.com/science/article/pii/S2211383524000078

Similar Items