Rapid profiling of the antigen regions recognized by serum antibodies using massively parallel sequencing of antigen-specific libraries.

Rapid profiling of the antigen regions recognized by serum antibodies using massively parallel sequencing of antigen-specific libraries.

There is a need for techniques capable of identifying the antigenic epitopes targeted by polyclonal antibody responses during deliberate or natural immunization. Although successful, traditional phage library screening is laborious and can map only some of the epitopes. To accelerate and improve epi...

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Bibliographic Details
Main Authors: Maria Domina, Veronica Lanza Cariccio, Salvatore Benfatto, Deborah D'Aliberti, Mario Venza, Erica Borgogni, Flora Castellino, Carmelo Biondo, Daniel D'Andrea, Luigi Grassi, Anna Tramontano, Giuseppe Teti, Franco Felici, Concetta Beninati
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4256389?pdf=render

Internet

http://europepmc.org/articles/PMC4256389?pdf=render

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