Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C

Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter: Di- and Tripeptide Permease C

Proton-coupled Oligopeptide Transporters (POTs) of the Major Facilitator Superfamily (MFS) mediate the uptake of short di- and tripeptides in all phyla of life. POTs are thought to constitute the most promiscuous class of MFS transporters, with the potential to transport more than 8400 unique substr...

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Bibliographic Details
Main Authors: Maxime Killer, Giada Finocchio, Haydyn D. T. Mertens, Dmitri I. Svergun, Els Pardon, Jan Steyaert, Christian Löw
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
peptide transporter
SLC15
nanobody
Pro-macrobody
single particle cryo-EM
DtpC
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.917725/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.917725/full

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