A linear B-cell epitope close to the furin cleavage site within the S1 domain of SARS-CoV-2 Spike protein discriminates the humoral immune response of nucleic acid- and protein-based vaccine cohorts

A linear B-cell epitope close to the furin cleavage site within the S1 domain of SARS-CoV-2 Spike protein discriminates the humoral immune response of nucleic acid- and protein-based vaccine cohorts

BackgroundUnderstanding the humoral immune response towards viral infection and vaccination is instrumental in developing therapeutic tools to fight and restrict the viral spread of global pandemics. Of particular interest are the specificity and breadth of antibody reactivity in order to pinpoint i...

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Bibliographic Details
Main Authors: Peter Lorenz, Felix Steinbeck, Franz Mai, Emil C. Reisinger, Brigitte Müller-Hilke
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
COVID-19
Spike protein
humoral immunity
antibody
linear epitope
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1192395/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1192395/full

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