Immunotherapeutic Potential of Oncolytic H-1 Parvovirus: Hints of Glioblastoma Microenvironment Conversion towards Immunogenicity

Immunotherapeutic Potential of Oncolytic H-1 Parvovirus: Hints of Glioblastoma Microenvironment Conversion towards Immunogenicity

Glioblastoma, one of the most aggressive primary brain tumors, is characterized by highly immunosuppressive microenvironment. This contributes to glioblastoma resistance to standard treatment modalities and allows tumor growth and recurrence. Several immune-targeted approaches have been recently dev...

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Bibliographic Details
Main Authors: Assia L. Angelova, Milena Barf, Karsten Geletneky, Andreas Unterberg, Jean Rommelaere
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Viruses
Subjects:
oncolytic virotherapy
oncolytic H-1 parvovirus
recurrent glioblastoma
tumor microenvironment
immune suppression
immunogenic conversion
oncolytic immunotherapy
Online Access:https://www.mdpi.com/1999-4915/9/12/382

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https://www.mdpi.com/1999-4915/9/12/382

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