Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways

Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways

In this study, we identified a novel pyrazole-based derivative (P3C) that displayed potent cytotoxicity against 27 human cancer cell lines derived from different tissue origins with 50% cytotoxic concentrations (CC<sub>50</sub>) in the low micromolar and nanomolar range, particularly in...

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Bibliographic Details
Main Authors: Denisse A. Gutierrez, Lisett Contreras, Paulina J. Villanueva, Edgar A. Borrego, Karla Morán-Santibañez, Jessica D. Hess, Rebecca DeJesus, Manuel Larragoity, Ana P. Betancourt, Jonathon E. Mohl, Elisa Robles-Escajeda, Khodeza Begum, Sourav Roy, Robert A. Kirken, Armando Varela-Ramirez, Renato J. Aguilera
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
pyrazole
triple-negative breast cancer
cytotoxicity
apoptosis
ROS
kinase activity regulation
Online Access:https://www.mdpi.com/2073-4409/11/2/254

Internet

https://www.mdpi.com/2073-4409/11/2/254

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