Negative and positive allosteric modulators of the α7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption

Negative and positive allosteric modulators of the α7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption

Rationale and Objectives: Ethanol acts directly on the α7 Nicotinic acetylcholine receptor (α7). Adolescent-binge alcohol exposure (ABAE) produces deleterious consequences during adulthood, and data indicate that the α7 receptor regulates these damaging events. Administration of an α7 Negative Allos...

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Bibliographic Details
Main Authors: Zachary A. Rodd, H. Scott Swartzwelder, R. Aaron Waeiss, Serhii O. Soloviov, Debomoy K. Lahiri, Eric A. Engleman, William A. Truitt, Richard L. Bell, Sheketha R. Hauser
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
alpha7 acetylcholine receptor
dopamine
alcohol
adolescence
prevention
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.954319/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2022.954319/full

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