HIF-1α-regulated lncRNA-TUG1 promotes mitochondrial dysfunction and pyroptosis by directly binding to FUS in myocardial infarction

HIF-1α-regulated lncRNA-TUG1 promotes mitochondrial dysfunction and pyroptosis by directly binding to FUS in myocardial infarction

Abstract Myocardial infarction (MI) is a fatal heart disease that affects millions of lives worldwide each year. This study investigated the roles of HIF-1α/lncRNA-TUG1 in mitochondrial dysfunction and pyroptosis in MI. CCK-8, DHE, lactate dehydrogenase (LDH) assays, and JC-1 staining were performed...

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Bibliographic Details
Main Authors: Yong-Wang Wang, Hong-Zhi Dong, Yong-Xing Tan, Xu Bao, Ying-Man Su, Xin Li, Fang Jiang, Jing Liang, Zhen-Cai Huang, Yan-Ling Ren, Yu-Li Xu, Qiang Su
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-00969-8

Internet

https://doi.org/10.1038/s41420-022-00969-8

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