Platelet-Derived Chemokine CXCL7 Dimer Preferentially Exists in the Glycosaminoglycan-Bound Form: Implications for Neutrophil–Platelet Crosstalk

Platelet-Derived Chemokine CXCL7 Dimer Preferentially Exists in the Glycosaminoglycan-Bound Form: Implications for Neutrophil–Platelet Crosstalk

Platelet-derived chemokine CXCL7 (also known as NAP-2) plays a crucial role in orchestrating neutrophil recruitment in response to vascular injury. CXCL7 exerts its function by activating the CXC chemokine receptor 2 (CXCR2) receptor and binding sulfated glycosaminoglycans (GAGs) that regulate recep...

Full description

Bibliographic Details
Main Authors: Aaron J. Brown, Krishna Mohan Sepuru, Kirti V. Sawant, Krishna Rajarathnam
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
chemokine
glycosaminoglycan
heparin
NMR
CXCL7
NAP-2
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01248/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01248/full

Similar Items