Rho GTPases and their downstream effectors in megakaryocyte biology
Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo fission to release platelets. Defects in platel...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2018.1478071 |
| _version_ | 1827816913491722240 |
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| author | Irina Pleines Deya Cherpokova Markus Bender |
| author_facet | Irina Pleines Deya Cherpokova Markus Bender |
| author_sort | Irina Pleines |
| collection | DOAJ |
| description | Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo fission to release platelets. Defects in platelet production can lead to a low platelet count (thrombocytopenia) with increased bleeding risk. Rho GTPases comprise a family of small signaling G proteins that have been shown to be master regulators of the cytoskeleton controlling many aspects of intracellular processes. The generation of Pf4-Cre transgenic mice was a major breakthrough that enabled studies in megakaryocyte-/platelet-specific knockout mouse lines and provided new insights into the central regulatory role of Rho GTPases in megakaryocyte maturation and platelet production. In this review, we will summarize major findings on the role of Rho GTPases in megakaryocyte biology with a focus on mouse lines in which knockout strategies have been applied to study the function of the best-characterized members Rac1, Cdc42 and RhoA and their downstream effector proteins. |
| first_indexed | 2024-03-12T00:27:02Z |
| format | Article |
| id | doaj.art-5ccf13a380af467c8eab8655b17179f1 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:27:02Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-5ccf13a380af467c8eab8655b17179f12023-09-15T10:31:59ZengTaylor & Francis GroupPlatelets0953-71041369-16352019-01-0130191610.1080/09537104.2018.14780711478071Rho GTPases and their downstream effectors in megakaryocyte biologyIrina Pleines0Deya Cherpokova1Markus Bender2University Hospital and Rudolf Virchow Center, University of WürzburgHarvard Medical SchoolUniversity Hospital and Rudolf Virchow Center, University of WürzburgMegakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo fission to release platelets. Defects in platelet production can lead to a low platelet count (thrombocytopenia) with increased bleeding risk. Rho GTPases comprise a family of small signaling G proteins that have been shown to be master regulators of the cytoskeleton controlling many aspects of intracellular processes. The generation of Pf4-Cre transgenic mice was a major breakthrough that enabled studies in megakaryocyte-/platelet-specific knockout mouse lines and provided new insights into the central regulatory role of Rho GTPases in megakaryocyte maturation and platelet production. In this review, we will summarize major findings on the role of Rho GTPases in megakaryocyte biology with a focus on mouse lines in which knockout strategies have been applied to study the function of the best-characterized members Rac1, Cdc42 and RhoA and their downstream effector proteins.http://dx.doi.org/10.1080/09537104.2018.1478071cdc42cytoskeletonmegakaryocyteplateletrac1rhoarho gtpases |
| spellingShingle | Irina Pleines Deya Cherpokova Markus Bender Rho GTPases and their downstream effectors in megakaryocyte biology Platelets cdc42 cytoskeleton megakaryocyte platelet rac1 rhoa rho gtpases |
| title | Rho GTPases and their downstream effectors in megakaryocyte biology |
| title_full | Rho GTPases and their downstream effectors in megakaryocyte biology |
| title_fullStr | Rho GTPases and their downstream effectors in megakaryocyte biology |
| title_full_unstemmed | Rho GTPases and their downstream effectors in megakaryocyte biology |
| title_short | Rho GTPases and their downstream effectors in megakaryocyte biology |
| title_sort | rho gtpases and their downstream effectors in megakaryocyte biology |
| topic | cdc42 cytoskeleton megakaryocyte platelet rac1 rhoa rho gtpases |
| url | http://dx.doi.org/10.1080/09537104.2018.1478071 |
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