Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity

Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity

The canonical NOD-like receptor family pyrin domain containing 3 (NLRP3) pathway involves a priming step to induce pro-IL-1β followed by a secondary signal such as K+ efflux to activate inflammasome formation. This then leads to the maturation of IL-1β and the formation of gasdermin D (GSDMD) pores...

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Bibliographic Details
Main Authors: Sarah Unterberger, Lisa Mullen, Melanie S. Flint, Sandra Sacre
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
interleukin-1β (IL-1β)
toll-like receptors (TLRs)
NLRP3 inflammasome
primary human monocytes
caspase-8
gasdermin D
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1092799/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1092799/full

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