Mesenchymal Transglutaminase 2 Activates Epithelial ADAM17: Link to G-Protein-Coupled Receptor 56 (ADGRG1) Signalling

Mesenchymal Transglutaminase 2 Activates Epithelial ADAM17: Link to G-Protein-Coupled Receptor 56 (ADGRG1) Signalling

A wound healing model was developed to elucidate the role of mesenchymal-matrix-associated transglutaminase 2 (TG2) in keratinocyte re-epithelialisation. TG2 drives keratinocyte migratory responses by activation of disintegrin and metalloproteinase 17 (ADAM17). We demonstrate that epidermal growth f...

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Bibliographic Details
Main Authors: Lea Bauer, Jessica Edwards, Andreas Heil, Sharon Dewitt, Heike Biebermann, Daniel Aeschlimann, Vera Knäuper
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
ADAM17
transglutaminase 2
adhesion G-protein-coupled receptor
GPR56
ADGRG1
EGFR-ligand
Online Access:https://www.mdpi.com/1422-0067/25/4/2329

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https://www.mdpi.com/1422-0067/25/4/2329

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