Comparative Stability of Two Anti-hyperpigmentation Agents: Kojic Acid as a Natural Metabolite and Its Di-Palmitate Ester, Under Oxidative Stress; Application to Pharmaceutical Formulation Design

Comparative Stability of Two Anti-hyperpigmentation Agents: Kojic Acid as a Natural Metabolite and Its Di-Palmitate Ester, Under Oxidative Stress; Application to Pharmaceutical Formulation Design

Purpose: Kojic acid (KA) a natural metabolite and its dipalmitate ester, kojic acid dipalmitate(Kadp) are both prescribed to treat skin hyperpigmentation. Stress test reveals the intrinsicstability of active ingredients and leads to selection of the suitable formulations. This researchevaluates the...

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Bibliographic Details
Main Authors: Sahar Tazesh, Elnaz Tamizi, Mohammadreza Siahi Shadbad, Nazli Mostaghimi, Farnaz Monajjemzadeh
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2022-03-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
stress test
oxidative stress
pharmaceutical preformulation
hplc
kinetic
degradation mechanism
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-12-329.pdf

Internet

https://apb.tbzmed.ac.ir/PDF/apb-12-329.pdf

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