Biochemical and structural characterization of two cif-like epoxide hydrolases from Burkholderia cenocepacia

Biochemical and structural characterization of two cif-like epoxide hydrolases from Burkholderia cenocepacia

Epoxide hydrolases catalyze the conversion of epoxides to vicinal diols in a range of cellular processes such as signaling, detoxification, and virulence. These enzymes typically utilize a pair of tyrosine residues to orient the substrate epoxide ring in the active site and stabilize the hydrolysis...

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Bibliographic Details
Main Authors: Noor M. Taher, Kelli L. Hvorecny, Cassandra M. Burke, Morgan S.A. Gilman, Gary E. Heussler, Jared Adolf-Bryfogle, Christopher D. Bahl, George A. O'Toole, Dean R. Madden
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Current Research in Structural Biology
Subjects:
α/β hydrolase
X-ray crystallography
Burkholderia cenocepacia
Epoxy-polyunsaturated fatty acids
Epoxide hydrolase
Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X21000039

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http://www.sciencedirect.com/science/article/pii/S2665928X21000039

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