Glutamine deprivation triggers NAGK-dependent hexosamine salvage
Tumors frequently exhibit aberrant glycosylation, which can impact cancer progression and therapeutic responses. The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a major substrate for glycosylation in the cell. Prior studies have identified the...
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-11-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/62644 |